Sleep — the foundation of metabolic health
Sleep is not 'wasted time' — it is an active hormonal, immune and metabolic recovery process. Chronic sleep restriction (< 6 h) raises insulin resistance, cortisol, appetite and inflammation as much as a poor diet.
- 1 week of < 6 h sleep = ~40% worse insulin sensitivity
- Deep sleep and REM — the glymphatic system clears the brain
- Cortisol, melatonin, growth hormone — in sync with the sun
Why sleep underpins every system
During sleep the body doesn't 'switch off' — the opposite happens: the glymphatic system flushes metabolic waste from the brain (including beta-amyloid), deep-sleep stages restore tissues via growth hormone, and REM consolidates memory and emotional regulation.
Sleep quality matters as much as duration. 8 h of fragmented sleep with low deep-sleep share is worse than 7 h of continuous deep sleep.
Early signs of poor sleep
- Waking without an alarm is hard; morning 'fog' lasts > 30 min
- Waking at 3–4 am (early cortisol rise)
- Falling asleep takes > 30 min or is 'too fast' (< 5 min = sleep debt)
- Night sweats, restless legs (RLS)
- Snoring, breathing pauses (possible sleep apnea)
- Afternoon carb cravings, evening snacking
- Reduced stress tolerance, irritability, poor focus
Sleep and insulin sensitivity
In the classic Van Cauter & Spiegel study (Lancet, 1999) healthy men were restricted to 4 h of sleep for 6 nights — glucose tolerance dropped by 40%, into pre-diabetic range. The effect resolved after normal sleep resumed.
Every hour of lost sleep raises next-day average insulin and appetite (leptin ↓, ghrelin ↑) — one reason sleep-deprived people spontaneously eat 300–500 kcal more.
Cortisol cycle and circadian rhythm
- Cortisol should peak in the morning (30 min after waking — CAR)
- In the evening (after 20:00) cortisol should fall — otherwise insomnia
- Evening blue light (screens) suppresses melatonin by 50–90%
- Morning natural light (10 min in the first hour) resets the cycle
Four pillars of better sleep
Before sleeping pills — try these four pillars consistently for 2–4 weeks. In most cases sleep improves substantially.
Light
10–20 min of natural morning light in the first hour. In the evening: screens on f.lux/night-shift, after 21:00 dim lights (< 100 lux), bedroom fully dark.
Temperature and rhythm
Bedroom 17–19 °C. Consistent wake and bedtime ± 30 min (including weekends). Dinner at least 2–3 h before bed.
Supplements for sleep (only when needed)
Before supplements — dial in light, caffeine, alcohol, training timing and stress. With the fundamentals in place, supplements work far better.
- Magnesium (bisglycinate or threonate, 200–400 mg evening) — relaxing, improves deep sleep
- L-theanine (200 mg) — reduces pre-sleep anxiety
- Glycine (3 g) — lowers body temperature, speeds sleep onset
- Apigenin (chamomile extract, 50 mg) — GABAergic effect
- Melatonin (0.3–1 mg) — SHORT-TERM (e.g. jet lag), not long-term
- Ashwagandha (300–600 mg) — lowers cortisol if stress is the driver
- Avoid: 'strong' 5–10 mg melatonin products — likely suppress endogenous production
Eating window and sleep
Late eating (< 2 h before bed) raises overnight glucose and insulin, reduces deep sleep and the GH pulse. Time-restricted eating (last meal 19:00–20:00) improves sleep quality for most people within weeks.
Very strict fasting (< 500 kcal/day) can worsen sleep in the first weeks — give the body 2–3 weeks to adapt.
Labs that add sleep context
- Salivary cortisol day profile (4 samples) — cortisol curve
- Fasting glucose and insulin, HOMA-IR — metabolic context
- Ferritin, TIBC — iron deficiency drives RLS and fragmented sleep
- TSH, free T3 — thyroid affects night temperature and sleep
- Vitamin D, magnesium (RBC), zinc — common deficiencies
- If snoring + breathing pauses — consider a sleep-apnea study (home polygraphy)
Go deeper: sleep and circadian webinars
Recorded material on sleep science, the cortisol rhythm and practical interventions.
Frequently asked questions
Go deeper: related material
Guides
Webinars
Courses
Related topics
Metabolic health is interconnected — explore the other deep-dives:
Insulin resistance
The root of metabolic disease — 5–10 years before diabetes appears.
ReadOverweight
Why calorie counting fails — hormones, insulin, leptin and adipose tissue.
ReadVagus nerve
The rest-and-repair system — digestion, heart, inflammation, stress.
ReadCholesterol & ApoB
Expanded lipid panel — ApoB, Lp(a), homocysteine, A vs B phenotype.
ReadChronic inflammation
The 'silent fire' behind cardiovascular disease, diabetes and autoimmunity.
ReadLow-carb and keto
Carbohydrate restriction — IR, T2D, fatty liver, metabolic syndrome.
ReadChronic sleep loss affects the whole body
If sleep has been poor for more than 3 months, it's worth reviewing the metabolic and hormonal context. In a consultation we look at the relevant labs and build a plan.
Book a consultationThis page is educational and general in nature. It is not personal medical advice, a diagnosis or a treatment plan. Discuss changes to your health, medication or supplements with your own doctor.