Academy · Articles
Scientific articles on lifestyle medicine
In-depth pieces from Dr Sergey Saadi on body biochemistry, nutrition, hormones and sleep — built on peer-reviewed research.
The hidden biochemistry of insulin resistance: why a standard blood-sugar test misleads
Most people assume that if their fasting glucose is normal (below 5.6 mmol/L), their carbohydrate metabolism is perfectly healthy. This is a dangerous myth. Type-2 diabetes and metabolic syndrome develop silently for 10–15 years before blood sugar ever starts rising.
ReadChronic low-grade inflammation — the invisible root cause of modern disease
Unlike acute inflammation (the body's normal defence against trauma or infection), systemic chronic inflammation is a silent destroyer. It causes no direct pain, but constantly drains the immune system and damages healthy tissues at the cellular level.
ReadChrono-nutrition and circadian rhythms: why meal timing decides your weight and sleep
Our body runs on a unique biological clock conducted by the suprachiasmatic nucleus (SCN) in the brain. But almost every cell and organ (liver, pancreas, gut) also has its own peripheral clock. The branch of science that studies the link between nutrition and these rhythms is called chrono-nutrition.
ReadSystemic low-grade inflammation and hs-CRP: the hidden metabolic killer
High-sensitivity C-reactive protein (hs-CRP) is one of the most important clinical windows into your body's invisible inflammatory process. Unlike acute inflammation it causes no pain, but it constantly damages the vascular endothelium, blocks insulin receptors and accelerates biological ageing.
ReadMuscle mass as a metabolic shield and glucose reservoir
Muscle is not just an organ of movement. It is the largest insulin-sensitive organ in the body and the main postprandial glucose buffer. Strength training opens a unique mechanism: activation of GLUT4 transporters independent of insulin.
ReadGut microbiome and the vagus nerve: the biochemistry of your second brain
The gut and brain do not just communicate through hormones — they are connected by a powerful two-way neural highway, the vagus nerve. Short-chain fatty acids (SCFAs) made by the microbiome are the chemical language of that conversation, regulating satiety, mood and systemic glucose control.
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