Comprehensive health check
Biohacking — evidence-based body and brain optimization
Biohacking is a strategic intervention in your own biology to live longer, think more clearly and feel better. Our approach is not gadgets and hype — it's personalised, marker-driven optimisation supervised by a physician.
- Data before intervention — labs, HRV, sleep, glucose
- Every change tracked against a measurable marker
- Lifestyle > supplements > devices > drugs — in that order
Your health map — one deep check
Before any long-term optimisation, you need a precise picture of where you are today. The Comprehensive Health Check is Synage's deepest single service: a physician-led package that gives you a data-backed action plan for the next 12+ months.
- Pre-visit questionnaire + audit of existing data
- Extended biomarker panel (30+ markers) — ordering and interpretation
- Body composition and metabolic assessment (optional 14-day CGM)
- Lifestyle audit: sleep, HRV, movement, nutrition, stress
- 60–90 min physician visit + written prioritised plan
- Follow-up visit at 3 months + plan adjustment
One-time price. Includes consultations, lab interpretation and a written plan. Instalments via Montonio.
Book the health check →What biohacking actually is
Biohacking is the deliberate, systematic attempt to influence your physiology — not to treat disease, but to keep health markers better than "normally bad". Unlike reactive medicine, it focuses on prevention and optimisation.
The term was popularised by Silicon Valley communities, but its principles — measure, intervene, measure again — are identical to evidence-based preventive medicine (P4: predictive, preventive, personalized, participatory).
Trouble starts when "biohacking" turns into product sales: TikTok ice baths, red-light panels without context, 20 supplements in the morning because Bryan Johnson said so. Our job is to separate proven interventions from expensive placebos.
5 pillars serious biohacking rests on
Before you buy cryo or NAD+ IVs, get the foundation right. 80% of results come from 20% of interventions — and those 20% are not gadgets.
1. Sleep & circadian rhythm
The only intervention that affects every biological system at once. 7–9 h quality sleep, 5–10 min of morning sun, bedroom under 19 °C, last meal ≥ 3 h before bed. Track: HRV, deep sleep, REM.
2. Metabolic health (glucose & insulin)
Unstable blood sugar → energy crashes, cravings, inflammation, faster ageing. Fix: protein-rich breakfast, carbs after movement, vinegar before carbs, 12–14 h overnight fast. Track: fasting glucose, HbA1c, fasting insulin, HOMA-IR.
3. Movement — strength + VO₂ max
Muscle mass is a metabolic shield and one of the strongest predictors of lifespan. Minimum: 3× weekly strength + 2× cardio (including 1× high-intensity intervals for VO₂ max). Track: grip strength, VO₂ max, muscle mass on DEXA.
4. Vagus nerve & stress tone
HRV is the best single marker for autonomic health. Raise it with breath work (4-7-8 or 5-5), 1–2 min cold shower, moderate cardio, social contact, singing. Track: morning HRV via Oura / Whoop.
5. Nutrition — anti-inflammatory baseline
Ultra-processed food and refined oils are today's biggest chronic-inflammation driver. Baseline: protein 1.6–2.0 g/kg, fish oil, fermented foods, polyphenols (berries, dark chocolate, olive oil). Track: hs-CRP, omega-3 index, homocysteine.
What to measure — the biohacking baseline panel
Without data, biohacking is just an expensive placebo. Start with these markers:
- Extended lipid panel: LDL, HDL, triglycerides, ApoB, Lp(a)
- Metabolic: fasting glucose, insulin, HbA1c, HOMA-IR
- Inflammation: hs-CRP, homocysteine, fibrinogen, ferritin
- Hormones: TSH, free T3, testosterone (men), estradiol (women), DHEA-S, cortisol
- Micronutrients: vitamin D, B12, magnesium, zinc, omega-3 index
- Body composition: DEXA (muscle, fat, visceral fat, bone density)
- Biological age (optional): epigenetic clocks (GrimAge, PhenoAge)
- Continuous tracking: sleep (Oura / Whoop), HRV, steps, VO₂ max estimate
The Synage approach — physician-led biohacking
The classic biohacking mistake is one of two: copying someone else's protocol (Bryan Johnson's Blueprint, Peter Attia's routine) without your own data — or buying 20 supplements and hoping. Neither works.
The Synage approach starts with thorough diagnostics: extended blood work, genetic testing (optional), body composition, sleep and HRV. From that we build a prioritised plan — what is your limiting factor right now, and what gives the biggest benefit at the lowest risk.
- Consultation (60 min): history, current plan, goals, risk factors
- Diagnostics: 20–40 markers (not 5), genetics and microbiome if relevant
- Individual plan: lifestyle → supplements → devices → (rarely) drugs
- Recheck 3–6 months later: what worked, what didn't
- Optional: ongoing subscription monitoring
Red flags in biohacking
Not every "biohack" is safe or evidence-based. Be careful when you see:
- ✕"This one supplement fixes everything" — biology doesn't work that way
- ✕Big promises without lab tracking
- ✕A stack of 20+ supplements in the morning with no rationale
- ✕€5000+ devices without any RCTs behind them
- ✕IV therapies (NAD+, glutathione) outside medical indication
- ✕Anti-ageing drugs (metformin, rapamycin) taken without supervision
- ✕"Healing" ice baths — proven only for mood and HRV, not disease
- ✕"Stem cells" in unlicensed third-country clinics
Frequently asked questions
Start biohacking under medical supervision
Book a consultation with Dr Sergey Saadi — get the full picture of your current health and a personalised optimisation plan.
Book a consultation →Disclaimer: This page is educational, not medical advice. For specific interventions consult your own physician. Supplements and drugs can interact.